Airway Memory CD4+ T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses
Identifieur interne : 001085 ( Main/Exploration ); précédent : 001084; suivant : 001086Airway Memory CD4+ T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses
Auteurs : Jincun Zhao [République populaire de Chine, États-Unis] ; Jingxian Zhao [États-Unis] ; Ashutosh K. Mangalam [États-Unis] ; Rudragouda Channappanavar [États-Unis] ; Craig Fett [États-Unis] ; David K. Meyerholz [États-Unis] ; Sudhakar Agnihothram [États-Unis] ; Ralph S. Baric [États-Unis] ; Chella S. David [États-Unis] ; Stanley Perlman [États-Unis]Source :
- Immunity [ 1074-7613 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (immunologie), Appareil respiratoire (immunologie), Cellules cultivées, Déterminants antigéniques des lymphocytes T (immunologie), Humains, Immunité, Infections à coronavirus (immunologie), Interféron gamma (métabolisme), Lignées consanguines de souris, Lymphocytes T CD4+ (immunologie), Lymphocytes T CD4+ (virologie), Lymphocytes T CD8+ (immunologie), Lymphocytes T CD8+ (virologie), Mémoire immunologique, Réactions croisées, Souris, Syndrome respiratoire aigu sévère (immunologie), Vaccination, Vaccins antiviraux (immunologie), Virion (immunologie), Virus du SRAS (immunologie).
- MESH :
- immunologie : Antigènes viraux, Appareil respiratoire, Déterminants antigéniques des lymphocytes T, Infections à coronavirus, Lymphocytes T CD4+, Lymphocytes T CD8+, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Virion, Virus du SRAS.
- métabolisme : Interféron gamma.
- virologie : Lymphocytes T CD4+, Lymphocytes T CD8+.
- Animaux, Cellules cultivées, Humains, Immunité, Lignées consanguines de souris, Mémoire immunologique, Réactions croisées, Souris, Vaccination.
English descriptors
- KwdEn :
- Animals, Antigens, Viral (immunology), CD4-Positive T-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (virology), CD8-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (virology), Cells, Cultured, Coronavirus Infections (immunology), Cross Reactions, Epitopes, T-Lymphocyte (immunology), Humans, Immunity, Immunologic Memory, Interferon-gamma (metabolism), Mice, Mice, Inbred Strains, Respiratory System (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Vaccination, Viral Vaccines (immunology), Virion (immunology).
- MESH :
- chemical , immunology : Antigens, Viral, Epitopes, T-Lymphocyte, Viral Vaccines.
- immunology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Coronavirus Infections, Respiratory System, SARS Virus, Severe Acute Respiratory Syndrome, Virion.
- chemical , metabolism : Interferon-gamma.
- virology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes.
- Animals, Cells, Cultured, Cross Reactions, Humans, Immunity, Immunologic Memory, Mice, Mice, Inbred Strains, Vaccination.
Abstract
Two zoonotic coronaviruses (CoVs)—SARS-CoV and MERS-CoV—have crossed species to cause severe human respiratory disease. Here, we showed that induction of airway memory CD4+ T cells specific for a conserved epitope shared by SARS-CoV and MERS-CoV is a potential strategy for developing pan-coronavirus vaccines. Airway memory CD4+ T cells differed phenotypically and functionally from lung-derived cells and were crucial for protection against both CoVs in mice. Protection was dependent on interferon-γ and required early induction of robust innate and virus-specific CD8+ T cell responses. The conserved epitope was also recognized in SARS-CoV- and MERS-CoV-infected human leukocyte antigen DR2 and DR3 transgenic mice, indicating potential relevance in human populations. Additionally, this epitope was cross-protective between human and bat CoVs, the progenitors for many human CoVs. Vaccine strategies that induce airway memory CD4+ T cells targeting conserved epitopes might have broad applicability in the context of new CoVs and other respiratory virus outbreaks.
Url:
DOI: 10.1016/j.immuni.2016.05.006
PubMed: 27287409
PubMed Central: 4917442
Affiliations:
- République populaire de Chine, États-Unis
- Caroline du Nord, Guangdong, Iowa, Michigan
- Iowa City, Jiangmen
- Université de l'Iowa
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001049
- to stream Pmc, to step Curation: 001049
- to stream Pmc, to step Checkpoint: 000739
- to stream PubMed, to step Corpus: 000C39
- to stream PubMed, to step Curation: 000C39
- to stream PubMed, to step Checkpoint: 000D05
- to stream Ncbi, to step Merge: 002C75
- to stream Ncbi, to step Curation: 002C75
- to stream Ncbi, to step Checkpoint: 002C75
- to stream Main, to step Merge: 001087
- to stream Main, to step Curation: 001085
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Airway Memory CD4<sup>+</sup> T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses</title><author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Zhao, Jingxian" sort="Zhao, Jingxian" uniqKey="Zhao J" first="Jingxian" last="Zhao">Jingxian Zhao</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Mangalam, Ashutosh K" sort="Mangalam, Ashutosh K" uniqKey="Mangalam A" first="Ashutosh K." last="Mangalam">Ashutosh K. Mangalam</name><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Channappanavar, Rudragouda" sort="Channappanavar, Rudragouda" uniqKey="Channappanavar R" first="Rudragouda" last="Channappanavar">Rudragouda Channappanavar</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Fett, Craig" sort="Fett, Craig" uniqKey="Fett C" first="Craig" last="Fett">Craig Fett</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K." last="Meyerholz">David K. Meyerholz</name><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Microbiology and Immunology and Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology and Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Microbiology and Immunology and Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology and Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="David, Chella S" sort="David, Chella S" uniqKey="David C" first="Chella S." last="David">Chella S. David</name><affiliation wicri:level="2"><nlm:aff id="aff5">Department of Immunology, Mayo Clinic, Rochester, MI 55905, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology, Mayo Clinic, Rochester, MI 55905</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27287409</idno><idno type="pmc">4917442</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917442</idno><idno type="RBID">PMC:4917442</idno><idno type="doi">10.1016/j.immuni.2016.05.006</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001049</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001049</idno><idno type="wicri:Area/Pmc/Curation">001049</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001049</idno><idno type="wicri:Area/Pmc/Checkpoint">000739</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000739</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:27287409</idno><idno type="wicri:Area/PubMed/Corpus">000C39</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C39</idno><idno type="wicri:Area/PubMed/Curation">000C39</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C39</idno><idno type="wicri:Area/PubMed/Checkpoint">000D05</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D05</idno><idno type="wicri:Area/Ncbi/Merge">002C75</idno><idno type="wicri:Area/Ncbi/Curation">002C75</idno><idno type="wicri:Area/Ncbi/Checkpoint">002C75</idno><idno type="wicri:doubleKey">1074-7613:2016:Zhao J:airway:memory:cd</idno><idno type="wicri:Area/Main/Merge">001087</idno><idno type="wicri:Area/Main/Curation">001085</idno><idno type="wicri:Area/Main/Exploration">001085</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Airway Memory CD4<sup>+</sup> T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses</title><author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Zhao, Jingxian" sort="Zhao, Jingxian" uniqKey="Zhao J" first="Jingxian" last="Zhao">Jingxian Zhao</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Mangalam, Ashutosh K" sort="Mangalam, Ashutosh K" uniqKey="Mangalam A" first="Ashutosh K." last="Mangalam">Ashutosh K. Mangalam</name><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Channappanavar, Rudragouda" sort="Channappanavar, Rudragouda" uniqKey="Channappanavar R" first="Rudragouda" last="Channappanavar">Rudragouda Channappanavar</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Fett, Craig" sort="Fett, Craig" uniqKey="Fett C" first="Craig" last="Fett">Craig Fett</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K." last="Meyerholz">David K. Meyerholz</name><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Pathology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Microbiology and Immunology and Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology and Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Microbiology and Immunology and Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology and Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="David, Chella S" sort="David, Chella S" uniqKey="David C" first="Chella S." last="David">Chella S. David</name><affiliation wicri:level="2"><nlm:aff id="aff5">Department of Immunology, Mayo Clinic, Rochester, MI 55905, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology, Mayo Clinic, Rochester, MI 55905</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author></analytic><series><title level="j">Immunity</title><idno type="ISSN">1074-7613</idno><idno type="eISSN">1097-4180</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Viral (immunology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>CD4-Positive T-Lymphocytes (virology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (virology)</term><term>Cells, Cultured</term><term>Coronavirus Infections (immunology)</term><term>Cross Reactions</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Humans</term><term>Immunity</term><term>Immunologic Memory</term><term>Interferon-gamma (metabolism)</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Respiratory System (immunology)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Vaccination</term><term>Viral Vaccines (immunology)</term><term>Virion (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes viraux (immunologie)</term><term>Appareil respiratoire (immunologie)</term><term>Cellules cultivées</term><term>Déterminants antigéniques des lymphocytes T (immunologie)</term><term>Humains</term><term>Immunité</term><term>Infections à coronavirus (immunologie)</term><term>Interféron gamma (métabolisme)</term><term>Lignées consanguines de souris</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Lymphocytes T CD4+ (virologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Lymphocytes T CD8+ (virologie)</term><term>Mémoire immunologique</term><term>Réactions croisées</term><term>Souris</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Vaccination</term><term>Vaccins antiviraux (immunologie)</term><term>Virion (immunologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>Epitopes, T-Lymphocyte</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term><term>Appareil respiratoire</term><term>Déterminants antigéniques des lymphocytes T</term><term>Infections à coronavirus</term><term>Lymphocytes T CD4+</term><term>Lymphocytes T CD8+</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Virion</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>Coronavirus Infections</term><term>Respiratory System</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>Virion</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interferon-gamma</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Interféron gamma</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Lymphocytes T CD4+</term><term>Lymphocytes T CD8+</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Cross Reactions</term><term>Humans</term><term>Immunity</term><term>Immunologic Memory</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Humains</term><term>Immunité</term><term>Lignées consanguines de souris</term><term>Mémoire immunologique</term><term>Réactions croisées</term><term>Souris</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>Two zoonotic coronaviruses (CoVs)—SARS-CoV and MERS-CoV—have crossed species to cause severe human respiratory disease. Here, we showed that induction of airway memory CD4<sup>+</sup> T cells specific for a conserved epitope shared by SARS-CoV and MERS-CoV is a potential strategy for developing pan-coronavirus vaccines. Airway memory CD4<sup>+</sup> T cells differed phenotypically and functionally from lung-derived cells and were crucial for protection against both CoVs in mice. Protection was dependent on interferon-γ and required early induction of robust innate and virus-specific CD8<sup>+</sup> T cell responses. The conserved epitope was also recognized in SARS-CoV- and MERS-CoV-infected human leukocyte antigen DR2 and DR3 transgenic mice, indicating potential relevance in human populations. Additionally, this epitope was cross-protective between human and bat CoVs, the progenitors for many human CoVs. Vaccine strategies that induce airway memory CD4<sup>+</sup> T cells targeting conserved epitopes might have broad applicability in the context of new CoVs and other respiratory virus outbreaks.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S. Agnihothram</name></author><author><name sortKey="Gopal, R" uniqKey="Gopal R">R. Gopal</name></author><author><name sortKey="Yount, B L" uniqKey="Yount B">B.L. Yount</name></author><author><name sortKey="Donaldson, E F" uniqKey="Donaldson E">E.F. Donaldson</name></author><author><name sortKey="Menachery, V D" uniqKey="Menachery V">V.D. Menachery</name></author><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author><author><name sortKey="Scobey, T D" uniqKey="Scobey T">T.D. Scobey</name></author><author><name sortKey="Gralinski, L E" uniqKey="Gralinski L">L.E. Gralinski</name></author><author><name sortKey="Denison, M R" uniqKey="Denison M">M.R. Denison</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M. Zambon</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, K G" uniqKey="Anderson K">K.G. Anderson</name></author><author><name sortKey="Sung, H" uniqKey="Sung H">H. Sung</name></author><author><name sortKey="Skon, C N" uniqKey="Skon C">C.N. Skon</name></author><author><name sortKey="Lefrancois, L" uniqKey="Lefrancois L">L. Lefrancois</name></author><author><name sortKey="Deisinger, A" uniqKey="Deisinger A">A. Deisinger</name></author><author><name sortKey="Vezys, V" uniqKey="Vezys V">V. Vezys</name></author><author><name sortKey="Masopust, D" uniqKey="Masopust D">D. Masopust</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolles, M" uniqKey="Bolles M">M. Bolles</name></author><author><name sortKey="Deming, D" uniqKey="Deming D">D. Deming</name></author><author><name sortKey="Long, K" uniqKey="Long K">K. Long</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S. Agnihothram</name></author><author><name sortKey="Whitmore, A" uniqKey="Whitmore A">A. Whitmore</name></author><author><name sortKey="Ferris, M" uniqKey="Ferris M">M. Ferris</name></author><author><name sortKey="Funkhouser, W" uniqKey="Funkhouser W">W. Funkhouser</name></author><author><name sortKey="Gralinski, L" uniqKey="Gralinski L">L. Gralinski</name></author><author><name sortKey="Totura, A" uniqKey="Totura A">A. Totura</name></author><author><name sortKey="Heise, M" uniqKey="Heise M">M. Heise</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R. Channappanavar</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Frieman, M B" uniqKey="Frieman M">M.B. Frieman</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Morrison, T E" uniqKey="Morrison T">T.E. Morrison</name></author><author><name sortKey="Whitmore, A" uniqKey="Whitmore A">A. Whitmore</name></author><author><name sortKey="Funkhouser, W" uniqKey="Funkhouser W">W. Funkhouser</name></author><author><name sortKey="Ward, J M" uniqKey="Ward J">J.M. Ward</name></author><author><name sortKey="Lamirande, E W" uniqKey="Lamirande E">E.W. Lamirande</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Heise, M" uniqKey="Heise M">M. Heise</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ge, X Y" uniqKey="Ge X">X.Y. Ge</name></author><author><name sortKey="Li, J L" uniqKey="Li J">J.L. Li</name></author><author><name sortKey="Yang, X L" uniqKey="Yang X">X.L. Yang</name></author><author><name sortKey="Chmura, A A" uniqKey="Chmura A">A.A. Chmura</name></author><author><name sortKey="Zhu, G" uniqKey="Zhu G">G. Zhu</name></author><author><name sortKey="Epstein, J H" uniqKey="Epstein J">J.H. Epstein</name></author><author><name sortKey="Mazet, J K" uniqKey="Mazet J">J.K. Mazet</name></author><author><name sortKey="Hu, B" uniqKey="Hu B">B. Hu</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Peng, C" uniqKey="Peng C">C. Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harcourt, G C" uniqKey="Harcourt G">G.C. Harcourt</name></author><author><name sortKey="Garrard, S" uniqKey="Garrard S">S. Garrard</name></author><author><name sortKey="Davenport, M P" uniqKey="Davenport M">M.P. Davenport</name></author><author><name sortKey="Edwards, A" uniqKey="Edwards A">A. Edwards</name></author><author><name sortKey="Phillips, R E" uniqKey="Phillips R">R.E. Phillips</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hufford, M M" uniqKey="Hufford M">M.M. Hufford</name></author><author><name sortKey="Kim, T S" uniqKey="Kim T">T.S. Kim</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J. Sun</name></author><author><name sortKey="Braciale, T J" uniqKey="Braciale T">T.J. Braciale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iwata Yoshikawa, N" uniqKey="Iwata Yoshikawa N">N. Iwata-Yoshikawa</name></author><author><name sortKey="Uda, A" uniqKey="Uda A">A. Uda</name></author><author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T. Suzuki</name></author><author><name sortKey="Tsunetsugu Yokota, Y" uniqKey="Tsunetsugu Yokota Y">Y. Tsunetsugu-Yokota</name></author><author><name sortKey="Sato, Y" uniqKey="Sato Y">Y. Sato</name></author><author><name sortKey="Morikawa, S" uniqKey="Morikawa S">S. Morikawa</name></author><author><name sortKey="Tashiro, M" uniqKey="Tashiro M">M. Tashiro</name></author><author><name sortKey="Sata, T" uniqKey="Sata T">T. Sata</name></author><author><name sortKey="Hasegawa, H" uniqKey="Hasegawa H">H. Hasegawa</name></author><author><name sortKey="Nagata, N" uniqKey="Nagata N">N. Nagata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lees, J R" uniqKey="Lees J">J.R. Lees</name></author><author><name sortKey="Farber, D L" uniqKey="Farber D">D.L. Farber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z. Shi</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M. Yu</name></author><author><name sortKey="Ren, W" uniqKey="Ren W">W. Ren</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C. Smith</name></author><author><name sortKey="Epstein, J H" uniqKey="Epstein J">J.H. Epstein</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Crameri, G" uniqKey="Crameri G">G. Crameri</name></author><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z. Hu</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, C" uniqKey="Ma C">C. Ma</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X. Tao</name></author><author><name sortKey="Zhang, N" uniqKey="Zhang N">N. Zhang</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T. Tseng</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macleod, M K" uniqKey="Macleod M">M.K. MacLeod</name></author><author><name sortKey="Kappler, J W" uniqKey="Kappler J">J.W. Kappler</name></author><author><name sortKey="Marrack, P" uniqKey="Marrack P">P. Marrack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masopust, D" uniqKey="Masopust D">D. Masopust</name></author><author><name sortKey="Picker, L J" uniqKey="Picker L">L.J. Picker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mckinstry, K K" uniqKey="Mckinstry K">K.K. McKinstry</name></author><author><name sortKey="Strutt, T M" uniqKey="Strutt T">T.M. Strutt</name></author><author><name sortKey="Kuang, Y" uniqKey="Kuang Y">Y. Kuang</name></author><author><name sortKey="Brown, D M" uniqKey="Brown D">D.M. Brown</name></author><author><name sortKey="Sell, S" uniqKey="Sell S">S. Sell</name></author><author><name sortKey="Dutton, R W" uniqKey="Dutton R">R.W. Dutton</name></author><author><name sortKey="Swain, S L" uniqKey="Swain S">S.L. Swain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moran, T P" uniqKey="Moran T">T.P. Moran</name></author><author><name sortKey="Collier, M" uniqKey="Collier M">M. Collier</name></author><author><name sortKey="Mckinnon, K P" uniqKey="Mckinnon K">K.P. McKinnon</name></author><author><name sortKey="Davis, N L" uniqKey="Davis N">N.L. Davis</name></author><author><name sortKey="Johnston, R E" uniqKey="Johnston R">R.E. Johnston</name></author><author><name sortKey="Serody, J S" uniqKey="Serody J">J.S. Serody</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mueller, S N" uniqKey="Mueller S">S.N. Mueller</name></author><author><name sortKey="Gebhardt, T" uniqKey="Gebhardt T">T. Gebhardt</name></author><author><name sortKey="Carbone, F R" uniqKey="Carbone F">F.R. Carbone</name></author><author><name sortKey="Heath, W R" uniqKey="Heath W">W.R. Heath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oh, H L" uniqKey="Oh H">H.L. Oh</name></author><author><name sortKey="Chia, A" uniqKey="Chia A">A. Chia</name></author><author><name sortKey="Chang, C X" uniqKey="Chang C">C.X. Chang</name></author><author><name sortKey="Leong, H N" uniqKey="Leong H">H.N. Leong</name></author><author><name sortKey="Ling, K L" uniqKey="Ling K">K.L. Ling</name></author><author><name sortKey="Grotenbreg, G M" uniqKey="Grotenbreg G">G.M. Grotenbreg</name></author><author><name sortKey="Gehring, A J" uniqKey="Gehring A">A.J. Gehring</name></author><author><name sortKey="Tan, Y J" uniqKey="Tan Y">Y.J. Tan</name></author><author><name sortKey="Bertoletti, A" uniqKey="Bertoletti A">A. Bertoletti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, H" uniqKey="Peng H">H. Peng</name></author><author><name sortKey="Yang, L T" uniqKey="Yang L">L.T. Yang</name></author><author><name sortKey="Wang, L Y" uniqKey="Wang L">L.Y. Wang</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Huang, J" uniqKey="Huang J">J. Huang</name></author><author><name sortKey="Lu, Z Q" uniqKey="Lu Z">Z.Q. Lu</name></author><author><name sortKey="Koup, R A" uniqKey="Koup R">R.A. Koup</name></author><author><name sortKey="Bailer, R T" uniqKey="Bailer R">R.T. Bailer</name></author><author><name sortKey="Wu, C Y" uniqKey="Wu C">C.Y. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Purwar, R" uniqKey="Purwar R">R. Purwar</name></author><author><name sortKey="Campbell, J" uniqKey="Campbell J">J. Campbell</name></author><author><name sortKey="Murphy, G" uniqKey="Murphy G">G. Murphy</name></author><author><name sortKey="Richards, W G" uniqKey="Richards W">W.G. Richards</name></author><author><name sortKey="Clark, R A" uniqKey="Clark R">R.A. Clark</name></author><author><name sortKey="Kupper, T S" uniqKey="Kupper T">T.S. Kupper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Deming, D" uniqKey="Deming D">D. Deming</name></author><author><name sortKey="Paddock, C D" uniqKey="Paddock C">C.D. Paddock</name></author><author><name sortKey="Cheng, A" uniqKey="Cheng A">A. Cheng</name></author><author><name sortKey="Yount, B" uniqKey="Yount B">B. Yount</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L. Vogel</name></author><author><name sortKey="Herman, B D" uniqKey="Herman B">B.D. Herman</name></author><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T. Sheahan</name></author><author><name sortKey="Heise, M" uniqKey="Heise M">M. Heise</name></author><author><name sortKey="Genrich, G L" uniqKey="Genrich G">G.L. Genrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scobey, T" uniqKey="Scobey T">T. Scobey</name></author><author><name sortKey="Yount, B L" uniqKey="Yount B">B.L. Yount</name></author><author><name sortKey="Sims, A C" uniqKey="Sims A">A.C. Sims</name></author><author><name sortKey="Donaldson, E F" uniqKey="Donaldson E">E.F. Donaldson</name></author><author><name sortKey="Agnihothram, S S" uniqKey="Agnihothram S">S.S. Agnihothram</name></author><author><name sortKey="Menachery, V D" uniqKey="Menachery V">V.D. Menachery</name></author><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author><author><name sortKey="Swanstrom, J" uniqKey="Swanstrom J">J. Swanstrom</name></author><author><name sortKey="Bove, P F" uniqKey="Bove P">P.F. Bove</name></author><author><name sortKey="Kim, J D" uniqKey="Kim J">J.D. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slutter, B" uniqKey="Slutter B">B. Slütter</name></author><author><name sortKey="Pewe, L L" uniqKey="Pewe L">L.L. Pewe</name></author><author><name sortKey="Kaech, S M" uniqKey="Kaech S">S.M. Kaech</name></author><author><name sortKey="Harty, J T" uniqKey="Harty J">J.T. Harty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stockinger, B" uniqKey="Stockinger B">B. Stockinger</name></author><author><name sortKey="Bourgeois, C" uniqKey="Bourgeois C">C. Bourgeois</name></author><author><name sortKey="Kassiotis, G" uniqKey="Kassiotis G">G. Kassiotis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J. Sui</name></author><author><name sortKey="Deming, M" uniqKey="Deming M">M. Deming</name></author><author><name sortKey="Rockx, B" uniqKey="Rockx B">B. Rockx</name></author><author><name sortKey="Liddington, R C" uniqKey="Liddington R">R.C. Liddington</name></author><author><name sortKey="Zhu, Q K" uniqKey="Zhu Q">Q.K. Zhu</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author><author><name sortKey="Marasco, W A" uniqKey="Marasco W">W.A. Marasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, J" uniqKey="Sun J">J. Sun</name></author><author><name sortKey="Madan, R" uniqKey="Madan R">R. Madan</name></author><author><name sortKey="Karp, C L" uniqKey="Karp C">C.L. Karp</name></author><author><name sortKey="Braciale, T J" uniqKey="Braciale T">T.J. Braciale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Swain, S L" uniqKey="Swain S">S.L. Swain</name></author><author><name sortKey="Mckinstry, K K" uniqKey="Mckinstry K">K.K. McKinstry</name></author><author><name sortKey="Strutt, T M" uniqKey="Strutt T">T.M. Strutt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, F" uniqKey="Tang F">F. Tang</name></author><author><name sortKey="Quan, Y" uniqKey="Quan Y">Y. Quan</name></author><author><name sortKey="Xin, Z T" uniqKey="Xin Z">Z.T. Xin</name></author><author><name sortKey="Wrammert, J" uniqKey="Wrammert J">J. Wrammert</name></author><author><name sortKey="Ma, M J" uniqKey="Ma M">M.J. Ma</name></author><author><name sortKey="Lv, H" uniqKey="Lv H">H. Lv</name></author><author><name sortKey="Wang, T B" uniqKey="Wang T">T.B. Wang</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name></author><author><name sortKey="Richardus, J H" uniqKey="Richardus J">J.H. Richardus</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Cao, W C" uniqKey="Cao W">W.C. Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teijaro, J R" uniqKey="Teijaro J">J.R. Teijaro</name></author><author><name sortKey="Turner, D" uniqKey="Turner D">D. Turner</name></author><author><name sortKey="Pham, Q" uniqKey="Pham Q">Q. Pham</name></author><author><name sortKey="Wherry, E J" uniqKey="Wherry E">E.J. Wherry</name></author><author><name sortKey="Lefrancois, L" uniqKey="Lefrancois L">L. Lefrançois</name></author><author><name sortKey="Farber, D L" uniqKey="Farber D">D.L. Farber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tonkin, D R" uniqKey="Tonkin D">D.R. Tonkin</name></author><author><name sortKey="Whitmore, A" uniqKey="Whitmore A">A. Whitmore</name></author><author><name sortKey="Johnston, R E" uniqKey="Johnston R">R.E. Johnston</name></author><author><name sortKey="Barro, M" uniqKey="Barro M">M. Barro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trandem, K" uniqKey="Trandem K">K. Trandem</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Fleming, E" uniqKey="Fleming E">E. Fleming</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, D L" uniqKey="Turner D">D.L. Turner</name></author><author><name sortKey="Farber, D L" uniqKey="Farber D">D.L. Farber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Liao, Y" uniqKey="Liao Y">Y. Liao</name></author><author><name sortKey="Yap, P L" uniqKey="Yap P">P.L. Yap</name></author><author><name sortKey="Png, K J" uniqKey="Png K">K.J. Png</name></author><author><name sortKey="Tam, J P" uniqKey="Tam J">J.P. Tam</name></author><author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilkinson, T M" uniqKey="Wilkinson T">T.M. Wilkinson</name></author><author><name sortKey="Li, C K" uniqKey="Li C">C.K. Li</name></author><author><name sortKey="Chui, C S" uniqKey="Chui C">C.S. Chui</name></author><author><name sortKey="Huang, A K" uniqKey="Huang A">A.K. Huang</name></author><author><name sortKey="Perkins, M" uniqKey="Perkins M">M. Perkins</name></author><author><name sortKey="Liebner, J C" uniqKey="Liebner J">J.C. Liebner</name></author><author><name sortKey="Lambkin Williams, R" uniqKey="Lambkin Williams R">R. Lambkin-Williams</name></author><author><name sortKey="Gilbert, A" uniqKey="Gilbert A">A. Gilbert</name></author><author><name sortKey="Oxford, J" uniqKey="Oxford J">J. Oxford</name></author><author><name sortKey="Nicholas, B" uniqKey="Nicholas B">B. Nicholas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Wong, B H" uniqKey="Wong B">B.H. Wong</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Hui, W T" uniqKey="Hui W">W.T. Hui</name></author><author><name sortKey="Kwan, G S" uniqKey="Kwan G">G.S. Kwan</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Couch, R B" uniqKey="Couch R">R.B. Couch</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Legge, K" uniqKey="Legge K">K. Legge</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L. Zhao</name></author><author><name sortKey="Jha, B K" uniqKey="Jha B">B.K. Jha</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A. Wu</name></author><author><name sortKey="Elliott, R" uniqKey="Elliott R">R. Elliott</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name></author><author><name sortKey="Silverman, R H" uniqKey="Silverman R">R.H. Silverman</name></author><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S.R. Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author><author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C. Wohlford-Lenane</name></author><author><name sortKey="Agnihothram, S S" uniqKey="Agnihothram S">S.S. Agnihothram</name></author><author><name sortKey="Fett, C" uniqKey="Fett C">C. Fett</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Gale, M J" uniqKey="Gale M">M.J. Gale</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T. Gallagher</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Guangdong</li><li>Iowa</li><li>Michigan</li></region><settlement><li>Iowa City</li><li>Jiangmen</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name></region></country><country name="États-Unis"><region name="Iowa"><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name></region><name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name><name sortKey="Channappanavar, Rudragouda" sort="Channappanavar, Rudragouda" uniqKey="Channappanavar R" first="Rudragouda" last="Channappanavar">Rudragouda Channappanavar</name><name sortKey="David, Chella S" sort="David, Chella S" uniqKey="David C" first="Chella S." last="David">Chella S. David</name><name sortKey="Fett, Craig" sort="Fett, Craig" uniqKey="Fett C" first="Craig" last="Fett">Craig Fett</name><name sortKey="Mangalam, Ashutosh K" sort="Mangalam, Ashutosh K" uniqKey="Mangalam A" first="Ashutosh K." last="Mangalam">Ashutosh K. Mangalam</name><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K." last="Meyerholz">David K. Meyerholz</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><name sortKey="Zhao, Jingxian" sort="Zhao, Jingxian" uniqKey="Zhao J" first="Jingxian" last="Zhao">Jingxian Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001085 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001085 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4917442
|texte= Airway Memory CD4+ T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27287409" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |